Catalytic antibodies to factor VIII in haemophilia A

被引：5

作者：

Lacroix-Desmazes, S ^{[1
]}

Kazatchkine, MD ^{[1
]}

Kaveri, SV ^{[1
]}

机构：

[1] Inst Biomed Cordeliers, INSERM, U430, F-75006 Paris, France

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2003年 / 14卷

关键词：

haemophilia A; factor VIII; factor VIII inhibitors; catalytic antibodies;

D O I：

10.1097/00001721-200306001-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of factor VIII (FVIII) inhibitors in haemophiliac patients following therapeutic administration of exogenous FVIII is one of the major factors complicating the treatment of this disease. Most FVII inhibitors described to date appear to be directed towards epitopes; involved in the procoagulant activity of FVIII. However, recent data suggest that some FVIII inhibitors may behave as catalytic antibodies, able to cleave FVIII by hydrolysis. This appears to be the first example of catalytic antibodies having a direct role in the etiology of a disease. Further characterization of these catalytic anti-FVIII antibodies may lead to the identification of novel therapeutic approaches for the future management of FVIII inhibitor patients. (C) 2003 Lippincott Williams Wilkins.

引用

页码：S31 / S34

页数：4

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