What Lies Beneath: Wnt/β-Catenin Signaling and Cell Fate in the Lower Dermis

被引:6
|
作者
Jahoda, Colin A. B. [1 ]
Gilmore, Adam C. [1 ]
机构
[1] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 3LE, England
基金
英国医学研究理事会;
关键词
STEM-CELL; ADIPOCYTE DIFFERENTIATION; SKIN; ADIPOGENESIS; FIBROBLASTS; SUFFICIENT; ACTIVATION; FIBROSIS;
D O I
10.1016/j.jid.2016.03.029
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Dermal cell populations are markedly heterogeneous, and they have the capacity to differentiate into dynamic and complex dermal cell compartments. However, the regulatory processes that govern the establishment of each dermal subset remain unknown. Mastrogiannaki et al. provide evidence of Wnt/beta-catenin signaling controlling adipogenic differentiation in the developing reticular dermis. They also show that overexpression of localized Wnt converts dermal adipose cells into a distinct fibroblast subtype, which leads to fibrosis and disrupted hair follicle cycling. These findings highlight the multifaceted roles of Wnt signaling in the normal development and pathology of skin, including the establishment of dermal identity. Further understanding of Wnt involvement and uncovering the roles of specific Wnt ligands could be useful for discovering new therapeutic targets in treating fibrosis-related disorders.
引用
收藏
页码:1084 / 1087
页数:4
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