Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling

被引：70
|
作者：
Jaworski, Alexander [1 ,2 ]
Tessier-Lavigne, Marc [1 ,2 ]
机构：
[1] Genentech Inc, Div Res, San Francisco, CA 94080 USA
[2] Rockefeller Univ, Lab Brain Dev & Repair, New York, NY 10021 USA
来源：
NATURE NEUROSCIENCE | 2012年 / 15卷 / 03期
关键词：
NEURONAL GROWTH CONES; GRASSHOPPER EMBRYOS; DROSOPHILA;
D O I：
10.1038/nn.3037
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Axons travel to their targets in bundles or fascicles, but the molecules regulating fasciculation remain incompletely characterized. We found that Slit2 and its Robo receptors are expressed by motor axons, and that inactivation of Slit2 or Robo1 and Robo2 in mice caused axons to defasciculate prematurely at muscle targets. In vitro, Slit2 secreted by motoneurons regulated fasciculation through Robo1 and Robo2. These results support the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mechanism.
引用
收藏
页码：367 / 369
页数：3
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