Microglia sense ADP-gradient to switch chemotaxis to TNF-α-release via two distinct Gi-coupled P2Y receptors

被引:0
|
作者
Tsuzuki, Chizuru [1 ]
Hibino, Hiroshi [1 ]
Kurachi, Yoshihisa [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Pharmacol, Suita, Osaka 5650871, Japan
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:224P / 224P
页数:1
相关论文
共 8 条
  • [1] ADP activates microglial migration and phagocytosis via Gi-coupled P2Y receptor
    Tsuzuki, Chizuru
    Hibino, Hiroshi
    Kurachi, Yoshihisa
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 256P - 256P
  • [2] Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors
    Honda, S
    Sasaki, Y
    Ohsawa, K
    Imai, Y
    Nakamura, Y
    Inoue, K
    Kohsaka, S
    JOURNAL OF NEUROSCIENCE, 2001, 21 (06): : 1975 - 1982
  • [3] ADP AND ATP ACTIVATE MICROGLIAL MIGRATION AND PHAGOCYTOSIS VIA Gi-COUPLED P2Y RECEPTOR
    Tsuzuki, Chizuru
    Hibino, Hiroshi
    Kurachi, Yoshihisa
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 195 - 195
  • [4] Two-pore potassium ion channels are inhibited by both Gq/11- and Gi-coupled P2Y receptors
    Shrestha, Sony Shakya
    Parmar, Miralkumar
    Kennedy, Charles
    Bushell, Trevor J.
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 43 (04) : 363 - 369
  • [5] Adenosine triphosphate inhibits cytokine release from lipopolysaccharide-activated microglia via P2y receptors
    Ogata, T
    Chuai, M
    Morino, T
    Yamamoto, H
    Nakamura, Y
    Schubert, P
    BRAIN RESEARCH, 2003, 981 (1-2) : 174 - 183
  • [6] Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior
    Malin, Sacha A.
    Molliver, Derek C.
    MOLECULAR PAIN, 2010, 6
  • [7] P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia
    Liu, Pei-Wen
    Yue, Ming-Xia
    Zhou, Rui
    Niu, Juan
    Huang, Du-Juan
    Xu, Tao
    Luo, Pei
    Liu, Xiao-Hong
    Zeng, Jun-Wei
    JOURNAL OF PAIN RESEARCH, 2017, 10 : 1755 - 1767
  • [8] The role of Gi/o-coupled P2Y receptors in ADPβS-induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats: Pharmacological correlation with the P2Y12 and P2Y13 receptor subtypes
    Villalon, C. M.
    Villanueva-Castillo, B.
    Rivera-Mancilla, E.
    Van den Brink, A. Maassen
    Haanes, K. A.
    BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 (16) : 2994 - 2995