Analgesic activity of acylated 2-benzoxazolinone derivatives

被引：18
|
作者：
Gökhan, N
Erdogan, H
Durlu, NT
Demirdamar, R
机构：
[1] Hacettepe Univ, Dept Pharmaceut Chem, Fac Pharm, Ankara, Turkey
[2] Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey
来源：
FARMACO | 1999年 / 54卷 / 1-2期
关键词：
2-benzoxazolinone; acylation; analgesic activity;
D O I：
10.1016/S0014-827X(98)00111-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ten new benzoxazolinone derivatives having a disubstituted benzoyl group at the six position of the ring were synthesized by reacting 2-benzoxazolinone with aromatic carboxylic acids in the presence of polyphosphoric acid. The structure of the compounds were elucidated by IR,H-1 NMR, MS and elemental analysis. Analgesic activity was evaluated by a modified Koster test. Seven compounds showed analgesic activities higher than that of acetylsalicylic acid. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：112 / 115
页数：4
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