Vaccination against enteric pathogens: from science to vaccine trials

被引：12
|
作者：
Lindberg, AA [1 ]
机构：
[1] Pasteur Merieux Connaught, F-69280 Marcy Letoile, France
来源：
CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 01期
关键词：
D O I：
10.1016/S1369-5274(98)80151-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Recent advances in scientific research and clinical trials have shown promise for vaccine development against enteric pathogens. identification of new virulence factors, such as the two distinct shigella enterotoxins, has allowed the development of new immunogen or new attenuated strains. Improved knowledge facilitated the development of safer attenuated live microorganism and construction of multivalent vaccines. Finally, an important advantance is the use of nonreplicating plasmid DNA vectors to express protective antigens in the host.
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页码：116 / 124
页数：9
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