Pigment epithelium-derived factor (PEDF) prevents advanced glycation end products (AGEs)-Elicited endothelial nitric oxide synthase (eNOS) reduction through its anti-oxidative properties

被引：0
|
作者：
Yamagishi, Sho-Ichi
Ueda, Seiji
Matsui, Takanori
Nakainura, Kazuo
Imaizumi, Tsutomu
Takeuchi, Masayoshi
Okuda, Seiya
机构：
[1] Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan
[2] Hokuriku Univ, Fac Pharmaceut Sci, Dept Pathophysiol Sci, Kanazawa, Ishikawa 92011, Japan
来源：
PROTEIN AND PEPTIDE LETTERS | 2007年 / 14卷 / 08期
关键词：
aGEs; eNOS; oxidative stress; PEDF; peroxynitrite;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.
引用
收藏
页码：832 / 835
页数：4
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