Synthesis of Novel Substituted Tetrahydropyrimidine Derivatives and Evaluation of Their Pharmacological and Antimicrobial Activities

被引：15

作者：

Mahmoud, Naglaa F. H. ^{[1
]}

Ghareeb, Eman A. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 01期

关键词：

RAPID COLORIMETRIC ASSAY; ANTIBACTERIAL; ANTIOXIDANT; ANTITUMOR; SURVIVAL; GROWTH;

D O I：

10.1002/jhet.3374

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrahydropyrimidine derivative 1 was employed as intermediate compound, which in turn was allowed to react with different electrophilic and nucleophilic reagents to synthesize new polyfunctionalized series of substituted pyrimidine-2-thione derivatives. Structures of the newly synthesized compounds have been elucidated by spectroscopic data and elemental analyses. The pharmacological and antimicrobial activities of synthesized products have been evaluated as drug candidates.

引用

页码：81 / 91

页数：11

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