A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes

被引：1
|
作者：
Kim, Jichul
机构：
[1] Independent Researcher, Changwon
来源：
BIOPHYSICAL REPORTS | 2021年 / 1卷 / 02期
关键词：
FULL-LENGTH; INTEGRIN; TALIN; TRANSDUCTION; ELASTICITY; MEMBRANES; RIGIDITY; FORCES; TENSION; BINDING;
D O I：
10.1016/j.bpr.2021.100006
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggested that the size of nanostructural constraints and mechanical pulling applied on lipid membranes affect the generation of cellular traction forces and signaling transduction at focal adhesions. This work provides predictions on how lipid mem-branes contribute to mechanotransduction at cellular focal adhesions.
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页数：9
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