Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific regions of the rat striatum after electroconvulsive stimuli

被引：10
|
作者：
Zachrisson, O [1 ]
Mathe, AA [1 ]
Lindefors, N [1 ]
机构：
[1] ST GORANS UNIV HOSP,KAROLINSKA HOSP,PSYCHIAT SECT,DEPT CLIN NEUROSCI,STOCKHOLM,SWEDEN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 319卷 / 2-3期
关键词：
brain; electroconvulsive stimuli; hybridization; in situ; mRNA expression; substance P; tachykinin receptor; (rat);
D O I：
10.1016/S0014-2999(96)00861-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of electroconvulsive stimuli on the expression of mRNAs coding for preprotachykinin-A and the substance P-sensitive tachykinin NK1 receptor were examined in subregions of the rat striatum. In the electroconvulsive stimuli-treated animals, a 43% decrease in preprotachykinin-A mRNA was detected in the dorso-lateral caudate-putamen as compared to sham electroconvulsive stimuli treated animals. A 75% decrease in numerical density of tachykinin NK1 receptor mRNA positive neurons was found in the caudal part of the nucleus accumbens core. These findings provide new evidence for selective effects of electroconvulsive stimuli on specific populations of neurons in the rat striatum.
引用
收藏
页码：191 / 195
页数：5
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