Jatrophane Diterpenes from Euphorbia esula as Antiproliferative Agents and Potent Chemosensitizers to Overcome Multidrug Resistance

被引：43

作者：

Vasas, Andrea ^{[1
]}

Sulyok, Edvard ^{[1
]}

Redei, Dora ^{[1
]}

Forgo, Peter ^{[1
]}

Szabo, Pal ^{[2
]}

Zupko, Istvan ^{[3
]}

Berenyi, Agnes ^{[3
]}

Molnar, Joseph ^{[4
]}

Hohmann, Judit ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary

[2] Hungarian Acad Sci, Inst Chem, Chem Res Ctr, H-1525 Budapest, Hungary

[3] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary

[4] Univ Szeged, Dept Med Microbiol & Immunobiol, H-6720 Szeged, Hungary

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 06期

基金：

匈牙利科学研究基金会;

关键词：

MACROCYCLIC DITERPENE; POLYESTERS; ESTERS; CONSTITUENTS; PRINCIPLES; MODULATORS; IRRITANT; BINDING; FAMILY;

D O I：

10.1021/np200202h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical study of whole, undried plants of Euphorbia esula led to the isolation of six new (1-6) jatrophane diterpene polyesters, named esulatins H-M, together with the known compounds 2 alpha,3 beta,5 alpha,7 beta,15 beta-pentaacetoxy-9 alpha-nicotinoyloxyjatropha-6(17),11-dien-14-one (7), salicinolide (8), and euphosalicin (9). The structures and relative configuration of 1-6 were established on the basis of extensive spectroscopic analysis, including HRESIMS and one- and two-dimensional NMR techniques. All these compounds, together with diterpenes (10-14) isolated previously from this plant, were evaluated for their antiproliferative activity against HeLa, Ishikawa, and MCF7 cells. The multidrug-resistance-reversing activities were also investigated on L5178 mouse lymphoma cells transfected with the pHa MDR1/A retrovinis DNA. Preliminary structure-activity relationship data are discussed.

引用

页码：1453 / 1461

页数：9

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