Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives

被引：9
|
作者：
Mistry, Shailesh [1 ]
Singh, Akhilesh Kumar [1 ]
机构：
[1] Parul Univ, Parul Inst Appl Sci, PO Limbda, Vadodara 391760, Gujarat, India
来源：
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 8卷 / 01期
关键词：
Androstene; Estrane; Hydralazine hydrochloride; Hydrazone; Antimicrobial activity; BIOLOGICAL-ACTIVITY; SIDE-CHAIN; ANTIFUNGAL ACTIVITY; THIOSEMICARBAZONES; ANTIBACTERIAL; ANTICANCER; SCHIFF;
D O I：
10.1186/s43094-021-00391-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. Result: The structures of the compounds were established based on the spectral data. The in vitro antimicrobial activity of some newly synthesized compounds against bacteria and fungi was studied. Conclusion: New compounds showed better or similar antimicrobial activity. Designing more efficient steroidal hydrazones from ketosteroid based on the current study may successfully lead to the development of antimicrobial agent.
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页数：10
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