A DOTA-peptide conjugate by copper-free click chemistry

被引：30

作者：

Martin, Molly E. ^{[2
]}

Parameswarappa, Sharavathi G. ^{[1
]}

O'Dorisio, M. Sue ^{[2
]}

Pigge, F. Christopher ^{[1
]}

Schultz, Michael K. ^{[3
,4
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Dept Pediat, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Dept Radiol, Iowa City, IA 52242 USA

[4] Univ Iowa, Carver Coll Med, Dept Radiat Oncol, Iowa City, IA 52242 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 16期

关键词：

DOTA; Copper-free; Click chemistry; Peptides; Chelators; Bioconjugates;

D O I：

10.1016/j.bmcl.2010.06.111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4805 / 4807

页数：3

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