Targeting the tumor microenvironment by immunotherapy: part 2

被引:0
|
作者
Leibovici, Judith [1 ]
Itzhaki, Orit [1 ]
Huszar, Monica [1 ]
Sinai, Judith [1 ]
机构
[1] Tel Aviv Univ, Sackler Fac Med, Dept Pathol, IL-69978 Tel Aviv, Israel
关键词
cancer immunotherapy; growth promoting targets; immune evasion targets; immune targets; nonimmune targets; tumor microenvironment; CD8(+) T-CELLS; FIBROBLAST ACTIVATION PROTEIN; CANCER-ASSOCIATED FIBROBLASTS; CYTOKINE GENE POLYMORPHISMS; LOW-DOSE CYCLOPHOSPHAMIDE; POTENT ANTITUMOR-ACTIVITY; RNAS SUPPRESSES GROWTH; NF-KAPPA-B; BREAST-CANCER; IN-VIVO;
D O I
10.2217/IMT.11.112
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cancer therapy was traditionally centered on the neoplastic cells. This included mainly surgery, radiation, and chemotherapy, in some cases hormone therapy and to a lesser extent immunotherapy - all traditionally targeted to the highly proliferating mutated tumor cells. In view of our present understanding of the powerfull influence of the tumor microenvironment (TME) on cancer behavior and response - and lack of response - to treatment, this previously ignored constituent of cancer now has to be considered as an important, even indispensable target for therapy. The TME may be targeted both to its immune and to its nonimmune components. The various immune evasion elements of the TME should be targeted as well.
引用
收藏
页码:1385 / 1408
页数:24
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