A protecting group-free synthesis of the antineoplastic agent combretastatin A4

被引：3
|
作者：
Guo, Xiaotao [1 ]
Zhang, Dan [1 ]
Yu, Zhifang [1 ]
Liu, Tianzhen [1 ]
Li, Dachang [1 ]
Li, Chunbao [1 ]
机构：
[1] Tianjin Univ, Coll Sci, Dept Chem, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2011年 / 04期
关键词：
antineoplastic agent; combretastatin A4; synthesis; Wittig reaction; irradiation; A-4; COLCHICINE; TUBULIN; ANALOGS;
D O I：
10.3184/174751911X13024592068428
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of combretastatin A4 (CA4) from commercially available inexpensive materials has been achieved via the Wittig reaction followed by irradiation of the (Z)/(E)-CA4 reaction mixture with sunlight. The method resulted in (Z)-CA4 in high yield. This method does not require protection of the phenolic hydroxy group. The synthesis is operationally simple and cost-efficient.
引用
收藏
页码：229 / 230
页数：2
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