Antitumor activity of tributyrin in murine melanoma model

被引：19
|
作者：
Giermasz, A
Nowis, D
Jalili, A
Basak, G
Marczak, M
Makowski, M
Czajka, A
Mlynarczuk, I
Hoser, G
Stok, T
Lewandowski, S
Jakóbisiak, M
机构：
[1] Med Univ Warsaw, Ctr Biostruct, Dept Immunol, PL-02004 Warsaw, Poland
[2] Med Univ Warsaw, Ctr Biostruct, Dept Histol & Embriol, Warsaw, Poland
[3] Med Univ Warsaw, Dept Dermatol, Warsaw, Poland
[4] Postgrad Ctr Med Study, Dept Clin Cytol, Warsaw, Poland
[5] Cent Clin Hosp, Mil Sch Med, Oncol Clin, Warsaw, Poland
来源：
CANCER LETTERS | 2001年 / 164卷 / 02期
关键词：
tributyrin; butyrate; melanoma; mouse; tumor therapy;
D O I：
10.1016/S0304-3835(01)00375-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Butyric acid has been known to inhibit growth and to induce differentiation of a variety of tumor cells. Butyrate-treated tumor cells have also been observed to undergo apoptosis. Although butyrate compounds have demonstrated antitumor activity in murine tumor models and have already been admitted to clinical trials in tumor patients, the exact mechanism of their antitumor effects has not been elucidated. The results of our study showed antitumor activity of tributyrin, a butyric acid prodrug, in murine melanoma model and are strongly suggestive that antiangiogenic effects could participate in antitumor effects of butyrate compounds in vivo. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：143 / 148
页数：6
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