Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model

被引：38
|
作者：
Mulero, Miquel [2 ]
Rodriguez-Yanes, Esperanza [2 ]
Nogues, Maria Rosa [2 ]
Giralt, Montserrat [2 ]
Romeu, Marta [2 ]
Gonzalez, Salvador [1 ]
Mallol, Jordi [2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dermatol Serv, New York, NY 10022 USA
[2] Univ Rovira & Virgili, Sch Med & Hlth Sci, Dept Pharmacol, E-43201 Reus, Spain
来源：
EXPERIMENTAL DERMATOLOGY | 2008年 / 17卷 / 08期
关键词：
antioxidant; natural plant extract; photoprotection;
D O I：
10.1111/j.1600-0625.2007.00684.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
In this report, we have addressed the effect of oral administration of a hydrophilic extract of the fern Polypodium leucotomos (PL) on the deleterious effects of ultraviolet radiation (UVR) on the levels of epidermal and plasmatic antioxidants in hairless rats. We have found that pretreatment with PL effectively reduced glutathione oxidation in both blood and epidermis, suggesting a potent systemic antioxidant effect. In addition, PL inhibited UVR-mediated Langerhans cell (LC) depletion. Our results demonstrate the efficacy of PL as an oral antioxidant and photoimmunoprotective agent and support its employment as a complement to topical sunscreens.
引用
收藏
页码：653 / 658
页数：6
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