Early histological changes of bronchopulmonary dysplasia and pulmonary hypertension may precede clinical diagnosis in preterm infants*

被引：4

作者：

Stone, Amelia ^{[2
,4
,5
,7
]}

Poulik, Janet ^{[3
,5
]}

Koussa, Sara ^{[2
,5
]}

Xin, Yuemin ^{[2
,5
]}

Sharma, Amit ^{[1
,2
,5
]}

Sood, Beena G. ^{[1
,2
,5
,6
]}

机构：

[1] Hutzel Womens Hosp, Childrens Hosp Michigan, Div Neonatal Perinatal Med, Detroit, MI USA

[2] Childrens Hosp Michigan, Hutzel Womens Hosp, Dept Pediat, Div Neonatal Perinatal Med, Detroit, MI USA

[3] Childrens Hosp Michigan, Hutzel Womens Hosp, Dept Pediat Pathol, Div Neonatal Perinatal Med, Detroit, MI USA

[4] Northwestern Univ, Dept Pediat, Chicago, IL USA

[5] Wayne State Univ, Sch Med, Detroit, MI USA

[6] Wayne State Univ, Dept Pediat, 340 E Canfield, Detroit, MI 48201 USA

[7] Northwestern Univ, Pediat, Chicago, IL USA

来源：

EARLY HUMAN DEVELOPMENT | 2022年 / 171卷

关键词：

Bronchopulmonarydysplasia; BPD; Pulmonaryhypertension; PH; Histology; Histological; Premature; Extremelypremature; Autopsy; Postmortem; Clinicaldefinition; OUTCOMES;

D O I：

10.1016/j.earlhumdev.2022.105612

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Bronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for >= 28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants <28 days of age, highlighting the need for early diagnosis and treatment.

引用

页数：4

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