1,3,5-Triazines: A promising scaffold for anticancer drugs development

被引：118

作者：

Cascioferro, Stella ^{[1
]}

Parrino, Barbara ^{[1
]}

Spano, Virginia ^{[1
]}

Carbone, Anna ^{[1
]}

Montalbano, Alessandra ^{[1
]}

Barraja, Paola ^{[1
]}

Diana, Patrizia ^{[1
]}

Cirrincione, Girolamo ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, Via Archirafi 32, I-90123 Palermo, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 142卷

关键词：

1,3,5-Triazines; Antitumor activity; Nitrogen heterocycles; Disubstituted 1,3,5-triazines; Trisubstituted 1,3,5-triazines; Heterofused 1,3,5-triazines; CARBONIC-ANHYDRASE INHIBITORS; COMPETITIVE MTOR INHIBITORS; STRUCTURE-BASED DESIGN; BREAST-CANCER CELLS; IN-VITRO EVALUATION; THYMIDINE PHOSPHORYLASE; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; KINASE INHIBITORS; ANTITUMOR EVALUATION;

D O I：

10.1016/j.ejmech.2017.09.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：523 / 549

页数：27

共 50 条

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SHAW, RA
SMITH, BC
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[2] CONDENSED 1,3,5-TRIAZINES - 1,3,4-THIADIAZOLO[3,2-A]-1,3,5-TRIAZINES AND ISOXAZOLO[2,3-A]-1,3,5-TRIAZINES
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SHEHATA, IA
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, 24 (02) : 501 - 504
[3] MONO-(ARYLTHIO)-1,3,5-TRIAZINES AND BIS-(ARYLTHIO)-1,3,5-TRIAZINES
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CHEMIKER-ZEITUNG, 1986, 110 (10): : 374 - 377
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WINKLEY, MW
ROBINS, RK
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1969, (SEP): : ME62 - &
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FORBES, AD
GOULD, P
HILLS, IR
JOURNAL OF THE CHEMICAL SOCIETY, 1965, (FEB): : 1113 - &
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PROCEEDINGS OF THE CHEMICAL SOCIETY OF LONDON, 1962, (OCT): : 340 - &
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[8] AZIDO TETRAZOLE TAUTOMERISM OF AZIDO-1,3,5-TRIAZINES - THE DETECTION OF TETRAZOLO[1,5-A]-1,3,5-TRIAZINES
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Reinprecht, Ladislav
Kizlink, Juraj
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Maes, W
Dehaen, W
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