Chemo-enzymatic synthesis of 3-deoxy-β-D-ribofuranosyl purines and study of their biological properties

被引：8
|
作者：
Barai, VN
Zinchenko, AI
Eroshevskaya, LA
Zhernosek, EV
Balzarini, J
De Clercq, E [1 ]
Mikhailopulo, IA
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
[2] Natl Acad Sci, Inst Microbiol, Minsk, BELARUS
[3] Natl Acad Sci, Inst Bioorgan Chem, Minsk, BELARUS
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期
关键词：
enzymatic transglycosylation; purine nucleosides; activity;
D O I：
10.1081/NCN-120022626
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diiminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino-6-oxopurine (3'-deoxyisoguanosine; 4), and 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-fluoroadenine (5). Compounds 2-5 were evaluated for their anti-HIV activity.
引用
收藏
页码：751 / 753
页数：3
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