Inflammation-dependent thrombosis

被引：22
|
作者：
Myers, DD
Wakefield, TW
机构：
[1] Univ Michigan, Sch Med, Vasc Surg Sect, ULAM,Med Ct, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Ctr, Jobst Vasc Res Labs, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Med Ctr, Unit Lab Anim Med, Ann Arbor, MI 48109 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2005年 / 10卷
关键词：
inflammation; thrombosis; vascular disease; inflammatory mediators; thrombogenesis; tissue factor; adhesion molecules; microparticles; review;
D O I：
10.2741/1732
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vessel wall endothelial damage initiates a local inflammatory response, which promotes a prothrombotic state driven by tissue factor, adhesion molecules, and proinflammatory cytokines. Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis.
引用
收藏
页码：2750 / 2757
页数：8
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