PULMONARY THROMBOEMBOLISM FOLLOWING RADIO-FREQUENCY ABLATION OF THE ATRIOVENTRICULAR NODE IN A PATIENT HETEROZYGOUS FOR THE FACTOR V LEIDEN AND THE MTHFR C677T MUTATIONS

被引：3
|
作者：
Pesut, D. P. [1 ]
Raljevic, S., V [2 ]
Kontic, M. Dj [2 ]
Bozic, D. Z. [2 ]
Buha, I. B. [2 ]
Stevic, R. S. [1 ,3 ]
机构：
[1] Univ Belgrade, Sch Med, Dept Internal Med, Belgrade 11001, Serbia
[2] Teaching Hosp Lung Dis, Clin Ctr Serbia, Res & Epidemiol Dept, Belgrade, Serbia
[3] Ctr Radiol & Magnet Resonance, Clin Ctr Serbia, Belgrade, Serbia
来源：
BALKAN JOURNAL OF MEDICAL GENETICS | 2011年 / 14卷 / 01期
关键词：
Thromboembolism; Radiofrequency ablation; Atrioventricular (AV) node; Factor V (FV) Leiden mutation; Risk factor; ACTIVATED PROTEIN-C; PROTHROMBIN G20210A; VENOUS THROMBOSIS; ATRIAL-FIBRILLATION; CATHETER ABLATION; VEIN-THROMBOSIS; RISK; THROMBOPHILIA; TACHYCARDIA; PREVALENCE;
D O I：
10.2478/v10034-011-0018-z
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Patients who undergo radiofrequency ablation of the atrioventricular (AV) node rarely develop acute major complications. A 41-year-old Caucasian male smoker, was admitted to the Pulmology Teaching Hospital at Belgrade, Serbia, for sharp persistent chest pain, fever and fatigue following AV node radiofrequency ablation for arrhythmia. Chest X-ray showed obtuse right costo-phrenic angle and laminar atelectasis in the right lower lung lobe. The plasma D-dimer level was elevated. A perfusion lung scan showed multiple bilateral perfusion defects and multislice computed tomography showed thrombotic mass in the right pulmonary artery. Genetic analysis revealed that he was heterozygous for the prothrombin Factor V (FV) Leiden and MTHFR C677T mutations. Therapy started with intravenous heparin, followed by warfarin. He had no other episodes over a 2-year follow-up. Lifelong oral anticoagulant therapy was recommended.
引用
收藏
页码：51 / 55
页数：5
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