Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada By the Canadian League Against Epilepsy Medical Therapeutics Committee, Invited Experts and Collaborators

被引：7

作者：

Appendino, Juan Pablo ^{[1
]}

Boelman, Cyrus ^{[2
]}

Brna, Paula M. ^{[3
]}

Burneo, Jorge G. ^{[4
]}

Claassen, Curtis S. ^{[5
,6
]}

Connolly, Mary B. ^{[7
]}

De Guzman, Michael V. T. ^{[8
]}

Federico, Paolo ^{[9
,10
]}

Floyd, Deirdre ^{[11
]}

Huntsman, Richard James ^{[12
]}

Javidan, Manouchehr ^{[13
]}

Jette, Nathalie ^{[14
]}

Jurasek, Laura L. ^{[15
]}

Keezer, Mark R. ^{[16
,17
,18
]}

Lau, Jonathan C. ^{[19
]}

McCoy, Blathnaid ^{[20
]}

McLachlan, Richard S. ^{[21
]}

Ng, Marcus C. ^{[22
]}

Dang Khoa Nguyen ^{[23
]}

Reid, Aylin Y. ^{[24
]}

Rho, Jong M. ^{[25
]}

Snead, O. Carter, III ^{[26
]}

Tellez-Zenteno, Jose F. ^{[27
]}

Wang, Laura ^{[28
]}

Zak, Maria Martha ^{[29
]}

机构：

[1] Univ Calgary, Alberta Childrens Hosp, Cumming Sch Med, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada

[2] Univ British Columbia, BC Childrens Hosp, UBC Dept Pediat, Div Neurol, Vancouver, BC, Canada

[3] Dalhousie Univ, IWK Hlth Ctr, Dept Pediat, Halifax, NS, Canada

[4] Western Univ, Schulich Sch Med & Dent, Dept Clin Neurol Sci & Epidemiol & Biostat, Epilepsy Program, London, ON, Canada

[5] Alberta Childrens Prov Gen Hosp, Dept Neurosci, Calgary, AB, Canada

[6] Alberta Childrens Prov Gen Hosp, Dept Pharm, Calgary, AB, Canada

[7] British Columbia Childrens Hosp, Div Pediat Neurol, Epilepsy Program, Vancouver, BC, Canada

[8] Hosp Sick Children, Dept Pharm, Toronto, ON, Canada

[9] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada

[10] Univ Calgary, Hotchkiss Brain Inst, Dept Radiol, Calgary, AB, Canada

[11] CEA, Halifax, NS, Canada

[12] Univ Saskatchewan, Cannabinoid Res Initiat Saskatchewan, Dept Pediat, Div Pediat Neurol, Saskatoon, SK, Canada

[13] Univ British Columbia, Vancouver Gen Hosp, Fac Med, Dept Med,Div Neurol, Vancouver, BC, Canada

[14] Icahn Sch Med Mt Sinai, Dept Neurol & Populat Hlth Sci & Policy, New York, NY 10029 USA

[15] Univ Alberta, Stollery Childrens Hosp, Edmonton, AB, Canada

[16] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ, Canada

[17] Univ Montreal, Dept Social & Preventat Med, Montreal, PQ, Canada

[18] Ctr Hosp Univ Montreal, Ctr Rech CHUM CRCHUM, Montreal, PQ, Canada

[19] Western Univ, Dept Clin Neurol Sci, Div Neurosurg, London, ON, Canada

[20] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Neurol, Toronto, ON, Canada

[21] Western Univ, London, ON, Canada

[22] Univ Manitoba, Dept Internal Med, Sect Neurol, Winnipeg, MB, Canada

[23] Ctr Hosp Univ Montreal, Div Neurol, Montreal, PQ, Canada

[24] Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Krembil Res Inst,Dept Med Neurol, Toronto, ON, Canada

[25] Univ Calgary, Alberta Childrens Hosp, Alberta Childrens Hosp Res Inst, Cumming Sch Med,Hotchkiss Brain Inst,Sect Paediat, Calgary, AB, Canada

[26] Univ Toronto, Hosp Sick Children, Dept Pediat, Toronto, ON, Canada

[27] Univ Saskatchewan, Royal Univ Hosp, Saskatchewan Epilepsy Program, Dept Med,Div Neurol, Saskatoon, SK, Canada

[28] Hosp Sick Children, Toronto, ON, Canada

[29] Hosp Sick Children, Div Neurol, Toronto, ON, Canada

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2019年 / 46卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cannabinoids; CLAE; Statement; CBD; Epilepsy; Use; SEIZURES; TRIAL; MARIJUANA; SAFETY;

D O I：

10.1017/cjn.2019.282

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Canada, recreational use of cannabis was legalized in October 2018. This policy change along with recent publications evaluating the efficacy of cannabis for the medical treatment of epilepsy and media awareness about its use have increased the public interest about this agent. The Canadian League Against Epilepsy Medical Therapeutics Committee, along with a multidisciplinary group of experts and Canadian Epilepsy Alliance representatives, has developed a position statement about the use of medical cannabis for epilepsy. This article addresses the current Canadian legal framework, recent publications about its efficacy and safety profile, and our understanding of the clinical issues that should be considered when contemplating cannabis use for medical purposes.

引用

页码：645 / 652

页数：8