Chemical investigation of different crude extracts from Teucrium ramosissimum leaves. Correlation with their antigenotoxic and antioxidant properties

被引：26
|
作者：
Ben Sghaier, M. [1 ]
Bhouri, W. [1 ]
Neffati, A. [1 ]
Boubaker, J. [1 ]
Skandrani, I. [1 ]
Bouhlel, I. [1 ]
Kilani, S. [1 ]
Chekir-Ghedira, L. [1 ,2 ]
Ghedira, K. [1 ]
机构：
[1] Fac Pharm, Dept Pharmacognosy, Monastir 5000, Tunisia
[2] Fac Med Dent, Dept Cellular & Mol Biol, Monastir 5000, Tunisia
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 01期
关键词：
Teucrium ramosissimum; SOS chromotest; Antioxidant capacity; Xanthine oxidase activity; NBT/Riboflavine; FREE-RADICALS; SUPEROXIDE-DISMUTASE; AQUEOUS EXTRACTS; ESSENTIAL OIL; STEM BARK; ASSAY; MECHANISMS; FLAVONOIDS; INHIBITORS; LENTISCUS;
D O I：
10.1016/j.fct.2010.10.016
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The effect of extracts obtained from Teucrium ramosissimum leaves on genotoxicity and SOS response induced by aflatoxin B-1 (0.5 mu g/assay) as well as nitrofurantoin (5 mu g/assay) was investigated in a bacterial assay system, i.e., the SOS chromotest with Escherichia coli PQ37. The T. ramosissimum tested extracts exhibited no genotoxicity either with or without the external S9 activation mixture. However, all the extracts, particularly the total oligomers flavonoids (TOF) extract significantly decreased the genotoxicity induced by aflatoxin B-1 and nitrofurantoin. Antioxidant capacity of the tested extracts was evaluated using the enzymatic (xanthine/xanthine oxidase assay) (X/XOD) and the non-enzymatic (NBT/Riboflavine assay) systems. TOF extract was the most effective one in inhibiting ramosissimum to prevent mutations and also its antioxidant effect. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：191 / 201
页数：11
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