Remifentanil preconditioning confers delayed cardioprotection in the rat

被引:44
|
作者
Yu, C. K.
Li, Y. -H.
Wong, G. T. C.
Wong, T. M.
Irwin, M. G.
机构
[1] Univ Hong Kong, Dept Anesthesiol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Physiol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
[3] Anhui Med Univ, Hefei, Peoples R China
关键词
analgesics opioid; remifentanil; heart; ischaemia; rat; receptors; opioid;
D O I
10.1093/bja/aem261
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background. Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors. Methods. Male rats received preconditioning either by ischaemia (IPC; 5 min occlusion, 5 min reperfusion x 3) or with remifentanil (RPC; 1, 5, 10, and 20 mu g kg(-1) min(-1), 20 min infusion). After 24 h, all animals were subjected to 30 min occlusion of the left coronary artery and 2 h of reperfusion. Subsequently, the time-course effect of RPC (10 mu g kg(-1) min(-1), 20 min infusion) was determined at 12, 16, 24, 32, 36, and 48 h intervals, using the same experimental procedure. The effect of RPC (10 mu g kg(-1) min(-1), 20 min infusion) and IPC in the presence of selective OP receptor antagonists was evaluated at the 24 h interval. Infarct size ( IS), as a percentage of the area at risk (AAR), was determined. Results. Pre-treatment with remifentanil at 1, 5, 10, and 20 mg kg 21 min 21 significantly reduced the IS/AAR at 24 h with the maximum effect at 10 mu g kg(-1) min(-1). Remifentanil at 10 mu g kg(-1) min(-1) significantly reduced the IS at 12 h [32.5 (SD 9.1)%]; 16 h [26.1 (2.8)%]; 24 h [19.5 (5.0)%]; 32 h [31.2 (9.1)%]; and 36 h [36.4 (9.4)%] after drug administration. The maximal reduction in IS was seen at 24 h and the effect completely disappeared at 48 h [36.4 (9.4)%]. The protective effect of RPC was abolished or significantly attenuated by blockade of any of the three OP receptors with selective antagonists. Conclusions. Like IPC, remifentanil produces delayed cardioprotection in anaesthetized rats 12-36 h after administration. The protective effect is mediated via all three OP receptors.
引用
收藏
页码:632 / 638
页数:7
相关论文
共 50 条
  • [1] Remifentanil confers delayed cardioprotection in vivo
    Kwan, Yu Che
    Chun, Wong Tin
    Ming, Wong Tak
    Michael, Irwin G.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 : S180 - S181
  • [2] Remifentanil preconditioning confers cardioprotection via the JAK/STAT but not PI3K/Akt pathway in rats
    Qiao, Shigang
    Liu, Yanan
    Wang, Tingting
    Mao, Xiaowen
    Wong, Gordon T.
    Xia, Zhengyuan
    Irwin, Michael G.
    FASEB JOURNAL, 2011, 25
  • [3] An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse
    Cai, Xiaojie
    Tian, Yuling
    Wu, Yue
    Bonner, Michael Y.
    Zhuo, Xiaozhen
    Yuan, Zuyi
    JOURNAL OF SURGICAL RESEARCH, 2021, 264 : 544 - 552
  • [4] Isoflurane confers delayed cardioprotection in the adult rat triggered by reactive oxygen species
    Shi, Y
    Hutchins, WC
    Su, J
    Baker, JE
    FASEB JOURNAL, 2004, 18 (04): : A263 - A263
  • [5] Remote preconditioning and delayed cardioprotection in skeletal muscle
    Gross, GJ
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 289 (06) : R1562 - R1563
  • [6] Remffentanil preconditioning confers cardioprotection via cardiac κ- and δ-opioid receptors
    Zhang, Y
    Irwin, MG
    Wong, TM
    Chen, M
    Cao, CM
    ANESTHESIOLOGY, 2005, 102 (02) : 371 - 378
  • [7] Remifentanil preconditioning confers cardioprotection via glycogen synthase kinase-3β associated with ERK and JNK pathways in rats with heart failure
    Jin, S-Y.
    He, S-F.
    Wu, H.
    Wang, B.
    Wu, Y-X.
    Zhang, S-J.
    Zhang, Y.
    BRITISH JOURNAL OF ANAESTHESIA, 2016, 116 (06) : E912 - E913
  • [8] Sevoflurane Preconditioning Confers Delayed Cardioprotection by Upregulating AMP-Activated Protein Kinase Levels to Restore Autophagic Flux in Ischemia-Reperfusion Rat Hearts
    Hong, Lei
    Sun, Ying
    An, Jian-Zhong
    Wang, Chen
    Qiao, Shi-Gang
    MEDICAL SCIENCE MONITOR, 2020, 26
  • [9] Adrenergic activation confers cardioprotection mediated by adenosine, but is not required for ischemic preconditioning
    Haessler, R
    Kuzume, K
    Wolff, RA
    Kuzume, K
    Chien, GL
    Davis, RF
    VanWinkle, DM
    CORONARY ARTERY DISEASE, 1996, 7 (04) : 305 - 314
  • [10] Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits
    Müllenheim, J
    Ebel, D
    Bauer, M
    Otto, F
    Heinen, A
    Frässdorf, J
    Preckel, B
    Schlack, W
    ANESTHESIOLOGY, 2003, 99 (03) : 624 - 631