Reaction of ephedrine hydrochloride with sodium crosscarmellose and its account in the analysis of ephedrine-containing preparations

被引：3

作者：

Golubitskii, G. B. ^{[1
]}

Budko, E. V. ^{[2
]}

Basova, E. M. ^{[3
]}

Ivanov, V. M. ^{[4
]}

机构：

[1] OAO Farmstandard Leksredstva, Kursk 305039, Russia

[2] Kursk State Med Univ, Kursk 305004, Russia

[3] Dibna Int Univ Nat Soc & Human Being, Dubna, Moscow Oblost, Russia

[4] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2008年 / 63卷 / 02期

关键词：

Ephedrine; Recovery Factor; Phosphoric Acid Solution; Quality Control Department; Neutral Ionic Pair;

D O I：

10.1134/S106193480802010X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

It is shown by HPLC and Fourier-transform IR spectrometry that ephedrine hydrochloride (EH) reacts with an auxiliary pharmaceutical substance, sodium crosscarmellose, in aqueous-organic solutions and in dry mixtures. This process may lead to the underestimation of the results of determining EH in the analysis of preparations containing these components. A probable mechanism of the reaction of EH with sodium cross-carmellose is considered, and possible techniques for eliminating its interfering effect are proposed.

引用

页码：162 / 165

页数：4

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