Candida albicans infection in patients with oral squamous cell carcinoma

Bacground/Aim. Systemic candidiasis in intensive care units remains an improtant problem due to antifungal resistance Patients undergoing radiotherapy for head and neck cancer are at increased risk of developing oral candidiasis and they more frequent have prior fungi colonization Due to identification of specific risk factors predisposing to fungal infection in order to threat such patients the aim of this study was to determine the presence of Candida species in patients with oral squamous cell carcinoma and compare it to the control subjects (patients with benign oral mucosal lesions). Methods. A total number of 30 consecutive oral cancer examined patients were included in this prospective study (24 men and 6 women with a mean age of 61 47 years, range 41-81 years) The control group consisted of 30 consecutive patients with histologically proven benign oral mucosal lesions (16 men and 14 women with a mean age of 54 53 years, range 16 83 years) The samples for mycological examination were obtained by using sterile cotton swabs from the cancer lesion surface and in the patients of the control group from the benign mucosal lesion surface. Samples were inoculated in Sabouraud dextrose agar For identification purposes, Mackenzie germ tube test was performend on all isolates Results The prevalence of Candida was significantly higher in oral cancer patients than in control subjects (chi(2)= 5 455, p = 0.020) Candida was found on nine of the 30 cancer surfaces, 5 (16.7%) were identified as non-albicans Candida and 4 (13 3%) as Candida albicans In the control group only Candida albicans was isolated from 2 (6 7%) patients In this study, no statistically significant differences in the presence of Candida species was found with respect to gender, age, smoking, alcohol consumption, wearing of dental protheses and the site of cancer lesion Conclusion. The increased prevalence of yeasts on the surfaces of oral carcinoma indicates a need for their suppression before any cancer treatment There was no evidence for an association between gender, age, smoking, alcohol consumption, wearing of dental protheses, the site of cancer lesion and the yeast presence