Isolation and biological characterization of an infectious molecular clone of HIV-1CRF08_BC from China

被引：0
|
作者：
Kusagawa, S [1 ]
Yang, R [1 ]
Takebe, Y [1 ]
机构：
[1] Natl Inst Infect Dis, Lab Mol Virol & Epidemiol, Ctr AIDS Res, Tokyo, Japan
来源：
XV INTERNATIONAL AIDS CONFERENCE: BASIC SCIENCE | 2004年
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We isolated the first HIV-1 infectious molecular clone (IMC) (designated as 00CN-HH040.NX22) for CRF08(-)BC that is responsible for IDU epidemic in southeastern China. 00CN-HH040.NX22 replicated to high titers in PBMCs and utilized only CCR5 as a coreceptor for entry. 00CN-HH040.NX22 showed the identical recombinant structure with CRF08(-)BC reference strain. A potential sequence signature unique to CRF08(-)BC was observed in the enhancer region of LTR. 00CN-HH040.NX22 will be a useful tool to delineate the biological and virological properties of CRF08(-)BC and may also be used in design for vaccine candidates to limit the epidemic in southeastern China.
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页码：39 / 42
页数：4
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