Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions

被引：169
|
作者：
Dai, Chao [1 ,2 ]
Xu, Zhaoqing [1 ]
Huang, Fei [1 ]
Yu, Zhengkun [1 ]
Gao, Yan-Feng [2 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Zhengzhou Univ, Dept Bioengn, Zhengzhou 450001, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 09期
关键词：
PHASE TRANSFER CATALYSIS; DIRECT ARYLATION; BIOLOGICAL-ACTIVITIES; S-ALKYLATION; FUNCTIONALIZATIONS; HETEROCYCLES; BENZOXAZOLE; DISULFIDES; INHIBITORS; COMPLEXES;
D O I：
10.1021/jo202624s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Lewis acid (Ag-I, Ni-II, or Fe-II) catalyzed, Cu-II-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers.
引用
收藏
页码：4414 / 4419
页数：6
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