Finding a Needle in a QT Interval Big Data Haystack The Role for Orthogonal Datasets

被引:0
|
作者
Roden, Dan M. [1 ,2 ,3 ]
Mosley, Jonathan D. [1 ]
Denny, Joshua C. [1 ,3 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
[2] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA
关键词
adverse drug reactions; electronic health records; FAERS; HERG; long QT syndrome; ADVERSE-EVENT REPORTS; TORSADES-DE-POINTES; DRUG-INTERACTIONS; POLYMORPHISM; SCN5A;
D O I
10.1016/j.jacc.2016.08.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1765 / 1768
页数:4
相关论文
共 29 条
  • [1] Finding the Needle in the Big Data Systems Haystack
    Kraska, Tim
    IEEE INTERNET COMPUTING, 2013, 17 (01) : 84 - 86
  • [2] QT interval prolongation: the needle out of the haystack?
    Malgarini, R. Bertini
    Meneguz, A.
    Tucci, P.
    Pimpinella, G.
    DRUG SAFETY, 2006, 29 (10) : 981 - 981
  • [3] The DAQ needle in the big-data haystack
    Meschi, E.
    21ST INTERNATIONAL CONFERENCE ON COMPUTING IN HIGH ENERGY AND NUCLEAR PHYSICS (CHEP2015), PARTS 1-9, 2015, 664
  • [4] Exploring Big Data with Helix: Finding Needles in a Big Haystack
    Ellis, Jason
    Fokoue, Achille
    Hassanzadeh, Oktie
    Kementsietsidis, Anastasios
    Srinivas, Kavitha
    Ward, Michael J.
    SIGMOD RECORD, 2014, 43 (04) : 43 - 54
  • [5] Finding the proverbial "needle in a haystack": Identifying presymptomatic individuals with long QT syndrome
    Kirsh, Joel A.
    HEART RHYTHM, 2013, 10 (02) : 239 - 240
  • [6] Finding pediatric thromboembolism: needles in a big data haystack
    Blankenhorn, Katrina
    Mitchell, William Beau
    PEDIATRIC RESEARCH, 2024, 96 (3) : 553 - 554
  • [7] Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack
    Atluri, Gowtham
    Padmanabhan, Kanchana
    Fang, Gang
    Steinbach, Michael
    Petrella, Jeffrey R.
    Lim, Kelvin
    MacDonald, Angus, III
    Samatova, Nagiza F.
    Doraiswamy, P. Murali
    Kumar, Vipin
    NEUROIMAGE-CLINICAL, 2013, 3 : 123 - 131
  • [9] Finding a Needle in a Haystack: The Role of Electrostatics in Target Lipid Recognition by PH Domains
    Lumb, Craig N.
    Sansom, Mark S. P.
    PLOS COMPUTATIONAL BIOLOGY, 2012, 8 (07)
  • [10] Finding a Needle in the Haystack? Defining the Role of Random Biopsies in IBD Dysplasia Surveillance
    Ahmed, Waseem
    Lukin, Dana J.
    INFLAMMATORY BOWEL DISEASES, 2021, 27 (06) : 787 - 790