Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma

被引：33

作者：

Raiol, Láuren Cláudia Costa ^{[1
]}

Silva, Evely Cristina Figueira ^{[1
]}

Da Fonseca, Diana Mendes ^{[1
]}

Leal, Mariana Ferreira ^{[2
]}

Guimaraes, Adriana Costa ^{[1
]}

Calcagno, Danielle Queiroz ^{[1
]}

Khayat, André Salim ^{[1
]}

Assumpcao, Paulo Pimentel ^{[3
]}

Smith, Marília De Arruda Cardoso ^{[2
]}

Burbano, Rommel Rodriguez ^{[1
]}

机构：

[1] Fed Univ Para, Inst Biol Sci, Human Cytogenet & Toxicol Genet Lab, BR-66075900 Belem, Para, Brazil

[2] Univ Fed Sao Paulo, Dept Morphol, Div Genet, Sao Paulo, SP, Brazil

[3] Fed Univ Para, Joao Barros Barreto Univ Hosp, Belem, Para, Brazil

来源：

CANCER GENETICS AND CYTOGENETICS | 2008年 / 181卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2007.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer is the second leading cause of death by cancer in Brazil. Early gastric cancer represents similar to 10% of gastric cancer cases in some services of Brazil, which underscores the need for early gastric cancer diagnosis that could lead to better prognosis. There are few published studies of cytogenetic alterations in early gastric cancer. To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil. Three signals of MYC and MYC immunoreactivity were observed in all five samples, regardless of histologic type, tumor extension, or lymph nodal status. These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：31 / 35

页数：5

共 16 条

[1] Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma
Danielle Queiroz Calcagno
Mariana Ferreira Leal
Aline Damaceno Seabra
André Salim Khayat
Elizabeth Suchi Chen
Samia Demachki
Paulo Pimentel Assumpo
Mario Henrique Giro Faria
Silvia Helena Barem Rabenhorst
Márcia Valéria Pitombeira Ferreira
Marília de Arruda Cardoso Smith
Rommel Rodríguez Burbano
World Journal of Gastroenterology, 2006, (38) : 6207 - 6211
[2] Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma
Calcagno, Danielle Queiroz
Leal, Mariana Ferreira
Seabra, Aline Damaceno
Khayat, Andre Salim
Chen, Elizabeth Suchi
Demachki, Samia
Assumpcao, Paulo Pimentel
Girao Faria, Mario Henrique
Barem Rabenhorst, Silvia Helena
Pitombeira Ferreira, Marcia Valeria
Cardoso Smith, Marilia de Arruda
Burbano, Rommel Rodriguez
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (38) : 6207 - 6211
[3] MYC AND GASTRIC ADENOCARCINOMA CARCINOGENESIS: STUDY IN INDIVIDUALS FROM NORTHERN BRAZIL
Burbano, Rommel Rodriguez
ANTICANCER RESEARCH, 2008, 28 (5C) : 3224 - 3225
[4] Numerical aberrations of chromosome 8 detected by conventional cytogenetics and fluorescence in situ hybridization in individuals from northern Brazil with gastric adenocarcinoma
Assumpcao, Paulo Pimentel
Ishak, Geraldo
Chen, Elizabeth Suchi
Takeno, Sylvia Satomi
Leal, Mariana Ferreira
Guimaraes, Adriana Costa
Calcagno, Danielle Queiroz
Khayat, Andre Salim
Demachki, Sarnia
de Arruda Cardoso Smith, Marilia
Burbano, Rommel Rodriguez
CANCER GENETICS AND CYTOGENETICS, 2006, 169 (01) : 45 - 49
[5] Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma
Calcagno, DQ
Leal, MF
Takeno, SS
Assumpçao, PP
Demachki, S
Smith, MDC
Burbano, RR
ANTICANCER RESEARCH, 2005, 25 (6B) : 4069 - 4074
[6] Interrelationships among chromosome aneuploidy, promoter hypermethylation, and protein expression of the CDKN2A gene in individuals from northern Brazil with gastric adenocarcinoma
Guimares, Adriana Costa
Lima, Eleonidas Moura
Khayat, Andre Salim
Henrique, Mario
Faria, Girao
Barem Rabenhorst, Silvia Helena
Pitombeira, Marcia Valeria
Assumpcao, Paulo Pimentel
Bahia, Marcelo de Oliveira
de Lima, Patricia Danielle Lima
Cardoso Smith, Marilia de Arruda
Burbanoa, Rommel Rodriguez
CANCER GENETICS AND CYTOGENETICS, 2007, 179 (01) : 45 - 51
[7] Interrelationship between TP53gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma
André S Khayat
Adriana C Guimarães
Danielle Q Calcagno
Aline D Seabra
Eleonidas M Lima
Mariana F Leal
Mário HG Faria
Silvia HB Rabenhorst
Paulo P Assumpção
Samia Demachki
Marília AC Smith
Rommel R Burbano
BMC Gastroenterology, 9
[8] Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma
Khayat, Andre S.
Guimaraes, Adriana C.
Calcagno, Danielle Q.
Seabra, Aline D.
Lima, Eleonidas M.
Leal, Mariana F.
Faria, Mario H. G.
Rabenhorst, Silvia H. B.
Assumpcao, Paulo P.
Demachki, Samia
Smith, Marilia A. C.
Burbano, Rommel R.
BMC GASTROENTEROLOGY, 2009, 9
[9] Interleukin-1β polymorphisms, Helicobacter pyloriinfection in individuals from Northern Brazil with gastric adenocarcinoma
L. Lobo Gatti
R. Rodríguez Burbano
P. Pimentel de Assumpção
M. de Arruda Cardoso Smith
S. L. Marques Payão
Clinical and Experimental Medicine, 2004, 4 : 93 - 98
[10] DNA mismatch repair gene methylation in gastric cancer in individuals from northern Brazil
Lima, Eleonidas Moura
Leal, Mariana Ferreira
Cardoso Smith, Marilia de Arruda
Burbano, Rommel Rodriguez
de Assumpcao, Paulo Pimentel
Jose Bello, Maria
Antonio Rey, Juan
de Lima, Francinaldo Ferreira
Casartelli, Cacilda
BIOCELL, 2008, 32 (03) : 237 - 243

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