New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

被引：9

作者：

Mencia, Gabriel ^{[1
,2
,3
]}

Lozano-Cruz, Tania ^{[1
,2
,3
]}

Valiente, Mercedes ^{[4
]}

de la Mata, Javier ^{[1
,2
,3
]}

Cano, Jesus ^{[1
,3
]}

Gomez, Rafael ^{[1
,2
,3
]}

机构：

[1] Univ Alcala, Dept Quim Organ & Quim Inorgan, IQAR, Campus Univ, Madrid 28805, Spain

[2] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid 28029, Spain

[3] Ramon & Cajal Hlth Res Inst IRYCIS, IRYCIS, Madrid 28034, Spain

[4] Univ Alcala, Dept Quim Analit Quim Fis & Ingn Quim, IQAR, Campus Univ, Madrid 28805, Spain

来源：

MOLECULES | 2020年 / 25卷 / 04期

关键词：

carbosilane; dendrimer; fluorine; micelle; DENDRIMERS; BEHAVIOR;

D O I：

10.3390/molecules25040807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of F-19 magnetic resonance imaging (F-19-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by F-19-MRI.

引用

页数：15