Effect of Tralokinumab Upon Eosinophilic Airway Inflammation in Participants with Moderate to Severe, Uncontrolled Asthma (MESOS)

被引：0
|
作者：
Russell, R. J. [1 ]
Fitzgerald, J. M. [2 ]
Backer, V. [3 ]
Wang, M. [4 ]
Braddock, M. [4 ]
Nordenmark, L. H. [5 ]
Cohen, D. [6 ]
Parikh, H. [7 ]
Colice, G. [6 ]
Brightling, C. E. [1 ]
机构：
[1] Univ Leicester, Leicester, Leics, England
[2] Inst Heart & Lung Hlth, Vancouver, BC, Canada
[3] Univ Copenhagen, Bispebjerg Hosp, Copenhagen, Denmark
[4] AstraZeneca, Cambridge, England
[5] AstraZeneca, Gothenburg, Sweden
[6] AstraZeneca, Gaithersburg, MD USA
[7] AstraZeneca, Mississauga, ON, Canada
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2018年 / 197卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A7714
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
    Russell, Richard J.
    Chachi, Latifa
    FitzGerald, J. Mark
    Backer, Vibeke
    Olivenstein, Ronald
    Titlestad, Ingrid L.
    Ulrik, Charlotte Suppli
    Harrison, Timothy
    Singh, Dave
    Chaudhuri, Rekha
    Leaker, Brian
    McGarvey, Lorcan
    Siddiqui, Salman
    Wang, Millie
    Braddock, Martin
    Nordenmark, Lars H.
    Cohen, David
    Parikh, Himanshu
    Colice, Gene
    Brightling, Christopher E.
    LANCET RESPIRATORY MEDICINE, 2018, 6 (07): : 499 - 510
  • [2] Markers of eosinophilic airway inflammation in patients with severe and mild to moderate asthma
    Sergeeva, Galina
    Emelyanov, Alexander
    Leshenkova, Evgenia
    Znakhurenko, Antonina
    Rebrova, Svetlana
    Kozireva, Ludmila
    Asatiani, Nana
    EUROPEAN RESPIRATORY JOURNAL, 2016, 48
  • [3] Effect of tralokinumab on GINA control in severe, uncontrolled asthma
    Brightling, Christopher E.
    Piper, Edward
    Wessman, Peter
    Colice, Gene
    EUROPEAN RESPIRATORY JOURNAL, 2017, 50
  • [4] Neutrophilic airway inflammation in severe uncontrolled asthma
    Janeva, Jovanovska E.
    Gjorcev, A.
    Kaeva, B.
    Goseva, Z.
    Zdraveska, M.
    Dimitrievska, D.
    Arskovski, Z.
    Pejkovska, S.
    Trajkov, D.
    ALLERGY, 2016, 71 : 358 - 359
  • [5] Refractory eosinophilic airway inflammation in severe asthma
    Payne, DNR
    Bush, A
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (12) : 1385 - 1385
  • [6] Tralokinumab unsuccessful for management of severe, uncontrolled asthma
    Chung, Kian Fan
    LANCET RESPIRATORY MEDICINE, 2018, 6 (07): : 480 - 481
  • [7] Refractory eosinophilic airway inflammation in severe asthma - Effect of parenteral corticosteroids
    ten Brinke, A
    Zwinderman, AH
    Sterk, PJ
    Rabe, KF
    Bel, EH
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (06) : 601 - 605
  • [8] Effect of tralokinumab on serum periostin and IgE levels in uncontrolled severe asthma
    Ranade, Koustubh
    Manetz, Scott
    Liang, Meina
    Lee, Rozanne Yen-Wah
    Kuziora, Michael
    She, Dewei
    Piper, Ed
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [9] Effect of CPAP on airway reactivity and airway inflammation in children with moderate-severe asthma
    Praca, Eduardo
    Jalou, Hasnaa
    Krupp, Nadia
    Delecaris, Angela
    Hatch, Joseph
    Slaven, James
    Gunst, Susan J.
    Tepper, Robert S.
    RESPIROLOGY, 2019, 24 (04) : 338 - 344
  • [10] Characterization of Airway and Esophageal Inflammation in Children With Severe Uncontrolled Asthma
    Erkman, J.
    Vaynblat, A.
    Liu, X.
    Thomas, K.
    Kazachkov, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
12345