Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α

被引：22
|
作者：
Park, Kun [2 ]
Lee, Ji-Hye [3 ]
Cho, Ho-Chan [4 ]
Cho, Sun-Young [1 ]
Cho, Jae-We [1 ]
机构：
[1] Keimyung Univ, Sch Med, Dept Dermatol, Taegu 700712, South Korea
[2] Eulji Univ, Coll Med, Dept Dermatol, Seoul, South Korea
[3] Eulji Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[4] Daegu Med Ctr, Dept Internal Med, Taegu, South Korea
来源：
ONCOLOGY LETTERS | 2010年 / 1卷 / 02期
关键词：
interleukin; tumor necrosis factor-alpha; glucosamine; HaCaT cells; NF-KAPPA-B; CURCUMIN; KINASE; DIFFERENTIATION; INHIBITION; THERAPY; STRESS; COX-2;
D O I：
10.3892/ol_00000051
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells Glucosamine has been recommended as a promising anti-inflammatory modulator, which has been applied in clinical trials for attenuation of the inflammatory process However, it is unknown whether glucosamine reduces the expression of TNF-alpha-induced inflammatory cytokines in HaCaT cells The anti-inflammatory effects of curcumin in HaCaT cells have been extensively investigated in several studies Thus, in this study we investigated the expression of IL-6, IL-8, TNF-alpha and IL-1 beta in glucosamine-treated HaCaT cells, and the effects of glucosamine were compared to those of curcumin-treated HaCaT cells Our data showed that the expression of IL-6, IL-8, TNF-alpha and IL-1 beta was decreased by glucosamine treatment in the HaCaT cells In contrast, the expression of IL-6, IL-8, TNF-alpha and IL-1 beta was not attenuated by glucosamine treatment in the TNF-alpha-treated HaCaT cells Notably, curcumin induced an increased expression of IL-8 and IL-1 beta in the HaCaT cells, but not that of IL-6 and TNF-alpha On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-alpha and IL-1 beta expression in the HaCaT cells However, the stimulation of TNF-alpha abolished the inhibitory effects of glucosamine on the expression of inflammatory cytokines in the HaCaT cells Thus, even though glucosamine induces the down-regulation of inflammatory cytokines in HaCaT cells, the anti-inflammatory role of glucosamine in TNF-alpha-mediated inflammatory skin diseases should be investigated
引用
收藏
页码：289 / 292
页数：4
相关论文
共 50 条
  • [1] Altered expression of cytokines IL-1α, IL-6, IL-8 and TNF-α in bovine follicular persistence
    Stassi, A. F.
    Baravalle, M. E.
    Belotti, E. M.
    Rey, F.
    Gareis, N. C.
    Diaz, P. U.
    Rodriguez, F. M.
    Leiva, C. J.
    Ortega, H. H.
    Salvetti, N. R.
    THERIOGENOLOGY, 2017, 97 : 104 - 112
  • [2] IL-6, IL-1β, TNF-α at IL-8 in osteopenia associated with loss of gonadal function.
    Ketlinsky, S
    Kalinina, N
    Drigina, L
    Nikiforova, I
    Davidova, N
    EUROPEAN CYTOKINE NETWORK, 1998, 9 (03) : 527 - 527
  • [3] Salivary levels of IL-1β, IL-6, IL-8, and TNF-α in patients with burning mouth syndrome
    Suh, Kyung-Im
    Kim, Young-Ku
    Kho, Hong-Seop
    ARCHIVES OF ORAL BIOLOGY, 2009, 54 (09) : 797 - 802
  • [4] Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression
    Xin-yi Zheng
    Chuan-yuan Mao
    Han Qiao
    Xi Zhang
    Li Yu
    Ting-yu Wang
    Er-yi Lu
    Acta Pharmacologica Sinica, 2017, 38 : 1150 - 1160
  • [5] Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression
    Zheng, Xin-yi
    Mao, Chuan-yuan
    Qiao, Han
    Zhang, Xi
    Yu, Li
    Wang, Ting-yu
    Lu, Er-yi
    ACTA PHARMACOLOGICA SINICA, 2017, 38 (08) : 1150 - 1160
  • [6] Serum IL-1β, IL-6, IL-8, and TNF-α levels in early diagnosis and management of neonatal sepsis
    Kurt, A. Nese Citak
    Aygun, A. Denizmen
    Godekmerdan, Ahmet
    Kurt, Abdullah
    Dogan, Yasar
    Yilmaz, Erdal
    MEDIATORS OF INFLAMMATION, 2007, 2007
  • [7] TNF-α, IL-6, and IL-8 Cytokines and Their Association with TNF-α-308 G/A Polymorphism and Postoperative Sepsis
    Baghel, Kavita
    Srivastava, Rajeshwar Nath
    Chandra, Abhijit
    Goel, Sudhir K.
    Agrawal, Jyotsna
    Kazmi, Hasan Raza
    Raj, Saloni
    JOURNAL OF GASTROINTESTINAL SURGERY, 2014, 18 (08) : 1486 - 1494
  • [8] TNF-α, IL-6, and IL-8 Cytokines and Their Association with TNF-α-308 G/A Polymorphism and Postoperative Sepsis
    Kavita Baghel
    Rajeshwar Nath Srivastava
    Abhijit Chandra
    Sudhir K. Goel
    Jyotsna Agrawal
    Hasan Raza Kazmi
    Saloni Raj
    Journal of Gastrointestinal Surgery, 2014, 18 : 1486 - 1494
  • [9] Bone and Cytokines: Beyond IL-1, IL-6 and TNF-α
    A. Rifas
    Calcified Tissue International, 1999, 64 : 1 - 7
  • [10] Bone and cytokines:: Beyond IL-1, IL-6 and TNF-α
    Rifas, L
    CALCIFIED TISSUE INTERNATIONAL, 1999, 64 (01) : 1 - 7
12345