Nongastrointestinal low-grade mucosa-associated lymphoid tissue lymphoma: Analysis of 75 patients

被引:211
|
作者
Zinzani, PL
Magagnoli, M
Galieni, P
Martelli, M
Poletti, V
Zaja, F
Molica, S
Zaccaria, A
Cantonetti, AM
Gentilini, P
Guardigni, L
Gherlinzoni, F
Ribersani, M
Bendandi, M
Albertini, P
Tura, S
机构
[1] Univ Bologna, Inst Hematol & Med Oncol Seragnoli, Bologna, Italy
[2] Univ Siena, Div Hematol, I-53100 Siena, Italy
[3] Univ Roma La Sapienza, Chair Hematol, Rome, Italy
[4] Maggiore Hosp, Div Pulm Med, Bologna, Italy
[5] Univ Udine, Chair Hematol, I-33100 Udine, Italy
[6] Catanzaro Hosp, Div Hematol, Catanzaro, Italy
[7] Ravenna Hosp, Div Hematol, Ravenna, Italy
[8] Univ Roma Tor Vergata, Chair Hematol, Rome, Italy
[9] Forli Hosp, Div Oncol, Forli, Italy
[10] Cesena Hosp, Hematol Unit, Cesena, Italy
关键词
D O I
10.1200/JCO.1999.17.4.1254
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Nongastrointestinal locations represent about 30% to 40% of all low-grade mucosa-associated lymphoid tissue (MALT) lymphomas. We report a retrospective analysis of 75 patients with nongastrointestinal low-grade MALT lymphoma, presenting their clinical, therapeutic, and follow-up data with respect to the initial location of the lymphoma. Patients end Methods: From January 1988 to October 1997, 75 patients with untreated nongastrointestinal low-grade MALT lymphoma were subjected to treatments ranging from local radiotherapy and local interferon alfa administration to chemotherapy. The lymphomas were located in the lung (19 patients), orbital soft tissue (16 patients), skin (seven patients), thyroid (seven patients), lachrymal gland (six patients), conjunctiva (six patients), salivary gland (six patients), breast (three patients), eyelid (two patients), larynx (one patient), bone marrow (one patient), and trachea (one patient), Results: Complete and partial remissions were achieved in 59 (79%) and 16 (21%) of the 75 patients, respectively, with an overall response rare of 100%. All but two of the patients are still alive, with a median follow-up of 47 months; these two patients died from other causes, The estimated time to treatment failure rate is 30% at 5 years. In the thyroid and lachrymal gland sites, no relapses were reported. Conclusion: Our data regarding the largest reported series of nongastrointestinal MALT lymphomas confirm the good prognosis of this particular clinicopathologic entity and the significant efficacy of different therapeutic approaches to specific sites. (C) 1999 by American Society of Clinical Oncology.
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页码:1254 / 1258
页数:5
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