Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes

被引：67
|
作者：
Sumida, Yuto [1 ]
Kato, Tomoe [1 ]
Yoshida, Suguru [1 ]
Hosoya, Takamitsu [1 ]
机构：
[1] Tokyo Med & Dent Univ, Biol Chem Lab, Grad Sch Biomed Sci, Inst Biomat & Bioengn,Chiyoda Ku, Tokyo 1010062, Japan
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 06期
关键词：
HYDROSTANNATION; EFFICIENT; (Z)-ALKENYLSILANES; HYDROSILATION; COMPLEXES; SILICON; OLEFINS; KETONES;
D O I：
10.1021/ol300279c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Highly regio- and stereoselective hydrosilylation applicable to a broad range of electron-deficient alkynes has been established using palladium catalysis. The synthetic utility of the method has been demonstrated by further transformations of alpha-silylalkenes, particularly Hiyama coupling and stereoinverting iododesilylation followed by Suzuki-Miyaura coupling, which enables stereodivergent syntheses of alpha-arylenoates.
引用
收藏
页码：1552 / 1555
页数：4
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