Review Article Immunological features of the multisystem inflammatory syndrome associated with SARS-CoV-2 in children

被引:0
|
作者
Lazova, Snezhina [1 ,2 ]
Gerenska, Dilyana [3 ]
Slabakova, Yoanna [4 ]
Velikova, Tsvetelina [5 ]
机构
[1] Univ Hosp NI Pirogov, Pediat Dept, Gen Eduard I Totleben Blvd 21, Sofia 1606, Bulgaria
[2] Med Univ Sofia, Fac Publ Hlth, Healthcare Dept, Bialo More 8 St, Sofia 1527, Bulgaria
[3] Dept Pharmacovigilance, PPD, Part Thermo Fisher Sci, Blvd Tsarigradsko Shoes 115r, Sofia 1784, Bulgaria
[4] Med Univ, Sofia, Bulgaria
[5] Univ Sofia, Univ Hosp Lozenetz, Med Fac, Dept Clin Immunol, Kozyak 1 St, Sofia 1407, Bulgaria
关键词
Multisystem inflammatory syndrome in children; MIS-C; MIS-A; cytokine storm; cytokines; SARS-CoV-2; COVID-19; long COVID; post-COVID;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
?? particular group of children developed severe multisystem inflammation associated with current or recent SARS-CoV-2 infection or contact with a COVID-19 patient in the previous few weeks. The condition was defined as multisystem inflammatory syndrome (MIS) in children (MIS-C). As the definition of CDC and WHO is fast widely accepted, the lack of an international consensus on the definition of the syndrome cases, however, leads to some difficulties for clinicians. Additionally, MIS-C shares some immunological, pathological features with the conditions, such as cytokine storm, long COVID and/or post-COVID syndrome. The picture is further complicated by the existence of the syndrome in adults (MIS-A). Therefore, we have compared these conditions from the immunological point of view in our review based on the published case reports, studies, systematic reviews and metaanalyses. This knowledge is essential not only for immunologists. The paediatricians must be familiar with the immunological bases of the syndrome and implement it in on-time recognition and diagnosis and minimize systemic damage of this life-threatening condition at the earliest stage possible. Further investigations still need to be done to find and develop the best effective therapy and prophylactics.
引用
收藏
页码:64 / 71
页数:8
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