Antibody-Mediated Response in Rat Liver Chronic Rejection

被引：3
|
作者：
Wan, R. [1 ,2 ]
Ying, W. [4 ]
Zeng, L. [3 ]
Deng, X. [1 ,2 ]
Chen, H. [1 ,2 ]
Gao, L. [1 ,2 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Ctr Organ Transplantat, Nanchang 330006, Jiangxi, Peoples R China
[3] Nanchang Univ, Affiliated Hosp 2, Dept Resp, Nanchang 330006, Jiangxi, Peoples R China
[4] JiangXi Elect Power Vocat Tech Coll, Nanchang, Peoples R China
来源：
TRANSPLANTATION PROCEEDINGS | 2011年 / 43卷 / 05期
关键词：
ALLOGRAFTS; C4D; ALLOANTIBODY; TRANSPLANTATION; CELLS; MODEL;
D O I：
10.1016/j.transproceed.2011.03.043
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Purpose. The aim was to study the effect of an antibody-mediated response on rat chronic liver rejection. Methods. Liver transplantation was performed in rats assigned to one of the 3 treatment groups: group A, Brown Norway (BN) to BN + CsA; group B, dark Agouti (DA) to BN; and group C, DA to BN + CsA. In addition to survival and histopathologic assessment, we examined donor-specific antibodies in sera and C4d staining in the transplanted liver. Results. In rats with chronic rejection, high levels of IgG1 were detected from day 7, reaching peak levels at postoperative days 60-90, showing significance compared with the acute rejection (P < .05) and the syngeneic groups (P < .01). There was more C4d deposition in vessels and portal stroma of the livers from recipients displaying chronic rejection compared with recipients showing acute rejection or of syngeneic origin (P < .05). Conclusion. Antibody-mediated responses might play important roles in the development of chronic liver allograft rejection.
引用
收藏
页码：1976 / 1979
页数：4
相关论文
共 50 条
  • [1] Chronic Antibody-Mediated Rejection in Rat Orthotopic Liver Transplantation
    Shimizu, A.
    Ishii, E.
    Kanzaki, G.
    Higo, S.
    Kajimoto, Y.
    Nagasaka, S.
    Masuda, Y.
    Fukuda, Y.
    TRANSPLANTATION, 2012, 94 (10) : 664 - 664
  • [2] Chronic Antibody-Mediated Responses May Mediate Chronic Rejection in Rat Orthotopic Liver Transplantation
    Shimizu, A.
    Ishii, E.
    Kuwahara, N.
    Arai, T.
    Kanzaki, G.
    Higo, S.
    Kajimoto, Y.
    Nagasaka, S.
    Masuda, Y.
    Fukuda, Y.
    TRANSPLANTATION PROCEEDINGS, 2013, 45 (05) : 1743 - 1747
  • [3] Antibody-mediated rejection in the liver allograft
    Huebscher, Stefan G.
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2012, 17 (03) : 280 - 286
  • [4] Development of a Rat Model of Antibody-Mediated Rejection After Liver Transplantation
    Tajima, T.
    Hata, K.
    Kusakabe, J.
    Miyauchi, H.
    Uemoto, S.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 : 527 - 527
  • [5] Proposed Diagnostic Criteria for Chronic Antibody-Mediated Rejection in Liver Allografts
    O'Leary, J. G.
    Cai, J.
    Freeman, R.
    Banuelos, N.
    Hart, B.
    Johnson, M.
    Jennings, L. W.
    Kaneku, H.
    Terasaki, P. I.
    Klintmalm, G. B.
    Demetris, A. J.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (02) : 603 - 614
  • [6] Molecular phenotype of chronic antibody-mediated rejection in liver transplant biopsies
    Engel, Bastian
    Alaswad, Ahmed
    Campos-Murguia, Alejandro
    Zoodsma, Martijn
    Hoeffer, Anne
    Chihab, Kinan
    Bosselmann, Emily
    Heinrich, Sophia
    Hartleben, Bjoern
    Jonigk, Danny
    Hallensleben, Michael
    Murielle, Verboom
    Geffers, Robert
    Wedemeyer, Heiner
    Xu, Chengjian
    Mensah, Angelina
    Kirchner, Theresa
    Jaeckel, Elmar
    Li, Yang
    Taubert, Richard
    JOURNAL OF HEPATOLOGY, 2024, 80 : S21 - S21
  • [7] The New Challenge in Pediatric Liver Transplantation: Chronic Antibody-Mediated Rejection
    Uebayashi, Elena Yukie
    Okajima, Hideaki
    Yamamoto, Miki
    Ogawa, Eri
    Okamoto, Tatsuya
    Haga, Hironori
    Hatano, Etsurou
    JOURNAL OF CLINICAL MEDICINE, 2022, 11 (16)
  • [8] Antibody-Mediated Rejection After Liver Transplant
    Lee, Michael
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2017, 46 (02) : 297 - +
  • [9] Plasmapheresis in Chronic Active Antibody-Mediated Rejection
    Karaveli, Guner
    Gok Oguz, Ebru
    Yildirim, Tolga
    Ercan, Zafer
    Merhametsiz, Ozgur
    Haspulat, Ayhan
    Ayli, Deniz
    TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, 2015, 24 (01): : 123 - 125
  • [10] A case of chronic antibody-mediated rejection in the making
    Bravou, Vasiliki
    Galliford, Jack
    McLean, Adam
    Willicombe, Michelle
    Taube, David
    Cook, Herbert T.
    Roufosse, Candice
    CLINICAL NEPHROLOGY, 2013, 80 (04) : 306 - 309
12345