The tie that binds: Design of biologically active single-chain human chorionic gonadotropins and a gonadotropin-receptor complex using protein engineering

被引：11
|
作者：
Puett, D [1 ]
Wu, CB [1 ]
Narayan, P [1 ]
机构：
[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
来源：
BIOLOGY OF REPRODUCTION | 1998年 / 58卷 / 06期
关键词：
D O I：
10.1095/biolreprod58.6.1337
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1337 / 1342
页数：6
相关论文
共 5 条
  • [1] A biologically active single chain human chorionic gonadotropin analog with altered receptor binding properties
    Narayan, P
    Gray, J
    Puett, D
    ENDOCRINOLOGY, 2000, 141 (01) : 67 - 71
  • [2] Design, characterization, and structure of a biologically active single-chain mutant of human IFN-γ
    Landar, A
    Curry, B
    Parker, MH
    DiGiacomo, R
    Indelicato, SR
    Nagabhushan, TL
    Rizzi, G
    Walter, MR
    JOURNAL OF MOLECULAR BIOLOGY, 2000, 299 (01) : 169 - 179
  • [3] High-level expression of a functional single-chain human chorionic gonadotropin-luteinizing hormone receptor ectodomain complex in insect cells
    Fralish, GB
    Narayan, P
    Puett, D
    ENDOCRINOLOGY, 2001, 142 (04) : 1517 - 1524
  • [4] Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex
    Meehan, TP
    Harmon, BG
    Overcast, ME
    Yu, KK
    Camper, SA
    Puett, D
    Narayan, P
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2005, 34 (02) : 489 - 503
  • [5] BIOSYNTHESIS OF A BIOLOGICALLY-ACTIVE SINGLE PEPTIDE-CHAIN CONTAINING THE HUMAN COMMON ALPHA-SUBUNITS AND CHORIONIC-GONADOTROPIN BETA-SUBUNITS IN TANDEM
    SUGAHARA, T
    PIXLEY, MR
    MINAMI, S
    PERLAS, E
    BENMENAHEM, D
    HSUEH, AJW
    BOIME, I
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) : 2041 - 2045
1