A Real-Time DSP-Based Biohybrid MEA System for Seizure Detection In Vitro

被引：0

作者：

Ahmadi-Farsani, Javad ^{[1
]}

Caron, Davide ^{[2
]}

Panuccio, Gabriella ^{[2
]}

Linares-Barranco, Bernabe ^{[1
]}

Serrano-Gotarredona, Teresa ^{[1
]}

机构：

[1] Univ Seville, CSIC, Inst Microelect Sevilla, Seville, Spain

[2] Ist Italiano Tecnol, Enhnced Regenerat Med, Genoa, Italy

来源：

2021 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (IEEE MEMEA 2021) | 2021年

基金：

欧盟地平线“2020”;

关键词：

biohybrid; real-time seizure detection; field potential to spike converter; neuromorphic engineering; closed-loop electrophysiology; microelectrode array; DSP-based neuron;

D O I：

10.1109/MeMeA52024.2021.9478753

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents a biohybrid arrangement made of a commercial microelectrode array (MEA) system for seizure-like activity detection in brain slices. The set-up takes advantage of an embedded fixed-point digital signal processor (DSP) to implement a neuron model and a field-potential to spike converter (FP2SP). The neuron model is biologically plausible and capable of generating various firing modalities. Based on a three-step algorithm, FP2SP extracts spikes from the epileptiform activity generated by brain slices. The seizure detector system is developed by connecting the FP2SP to the model neuron and properly tuning the FP2SP parameters. The results show that all the blocks of this system can operate properly in real-time mode and recognize seizure-like activity.

引用

页数：5

共 50 条

[1] Real-time development of a DSP-based ringing detection and warning system
Romero, R
Barreto, A
6TH WORLD MULTICONFERENCE ON SYSTEMICS, CYBERNETICS AND INFORMATICS, VOL III, PROCEEDINGS: IMAGE, ACOUSTIC, SPEECH AND SIGNAL PROCESSING I, 2002, : 356 - 361
[2] DSP-based system for real-time video communications
Kassim, AA
Chua, KS
Fong, FK
Ranganath, S
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, 1999, 10 (01) : 47 - 53
[3] DSP-based system for real-time video communications
Natl Univ of Singapore, Singapore, Singapore
Int J Imaging Syst Technol, 1 (47-53):
[4] A real-time DSP-based system for voice activity detection: Design and implement
1600, Science and Engineering Research Support Society, 20 Virginia Court, Sandy Bay, Tasmania, Australia (06):
[5] A Real-time DSP-based Hand Gesture Recognition System
Xuan-Thuan Nguyen
Lam-Hoai-Phong Nguyen
Trong-Tu Bui
Huu-Thuan Huynh
2012 IEEE INTERNATIONAL SYMPOSIUM ON SIGNAL PROCESSING AND INFORMATION TECHNOLOGY (ISSPIT), 2012, : 286 - 291
[6] Data acquisition and real-time computing by a DSP-based system
Aiello, S.
Anzalone, A.
Bartolucci, M.
Cardella, G.
Cavallaro, S.
DeFilippo, E.
Femino, S.
Geraci, M.
Giustolisi, F.
Guazzoni, P.
Manno, M.Iacono
Lanzalone, G.
Lanzano, G.
Lo Nigro, S.
Manfredi, G.
Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 1998, 136-138 : 1172 - 1176
[7] Optimizing DSP-based system design for real-time applications
Harris, S
Rao, R
Dokic, M
Ritchie, T
ELECTRONIC DESIGN, 1997, 45 (25) : 52 - &
[8] Data acquisition and real-time computing by a DSP-based system
Aiello, S
Anzalone, A
Bartolucci, M
Cardella, G
Cavallaro, S
DeFilippo, E
Femino, S
Geraci, M
Giustolisi, F
Guazzoni, P
Manno, MI
Lanzalone, G
Lanzano, G
Lo Nigro, S
Manfredi, G
Pagano, A
Papa, M
Pirrone, S
Politi, G
Porto, F
Rizzo, F
Sambataro, S
Sperduto, L
Sutera, C
Zetta, L
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1998, 136 : 1172 - 1176
[9] DSP-based real-time video encoding
Zhou, MH
Talluri, R
IMAGE AND VIDEO COMMUNICATIONS AND PROCESSING 2000, 2000, 3974 : 124 - 132
[10] A REAL-TIME MULTICHANNEL DSP-BASED NEURAL SIGNAL ANALYSIS SYSTEM
WILLMING, DA
WHEELER, BC
PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, PTS 1-4, 1988, : 1169 - 1170

← 1 2 3 4 5 →