How do macrophages distinguish the living from the dead?

被引：10
|
作者：
Cheers, C
Zhan, Y
机构：
[1] Dept. of Microbiology, University of Melbourne, Parkville
来源：
TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 11期
关键词：
D O I：
10.1016/0966-842X(96)10067-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Injection of live but not dead bacteria induces a wave of IL-12 and subsequently, IFN-gamma production. Surprisingly, in vitro, both live and dead bacteria elicit IL-12 from macrophages. Better understanding of how macrophages distinguish live from dead bacteria would help explain this difference and possibly bypass the need for live vaccines against intracellular bacteria.
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页码：453 / 455
页数：3
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