Validation of an Antimicrobial Stewardship-Driven Verigene Blood-Culture Gram-Negative Treatment Algorithm to Improve Appropriateness of Antibiotics

被引：16
|
作者：
Claeys, Kimberly C. [1 ]
Schlaffer, K. E. [2 ]
Heil, E. L. [1 ]
Leekha, S. [3 ,4 ]
Johnson, J. K. [5 ]
机构：
[1] Univ Maryland, Sch Pharm, Dept Pharm Practice & Sci, Baltimore, MD 21201 USA
[2] Univ Maryland Med Syst, Dept Med, Baltimore, MD USA
[3] Univ Maryland, Dept Epidemiol, Sch Med, Baltimore, MD 21201 USA
[4] Dept Publ Hlth, Baltimore, MD USA
[5] Univ Maryland, Dept Pathol, Sch Med, Baltimore, MD 21201 USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 10期
关键词：
diagnostic stewardship; multiplex PCR; rapid diagnostic; STREAM INFECTIONS; KLEBSIELLA-PNEUMONIAE; SEVERE SEPSIS; MORTALITY; OUTCOMES;
D O I：
10.1093/ofid/ofy233
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rapid diagnostic testing (RDT) allows for early adjustment of antibiotic therapy. This study examined the potential impact of a stewardship-driven antibiotic treatment algorithm, incorporating RDT into the management of Gram-negative bacteremia. The proposed algorithm would have resulted in 88.4% of cases receiving appropriate antibiotic therapy versus 78.1% by standard of care (P = .014).
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页数：3
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