How to Ask the Right Question and Find the Right Answer: Clinical Research for Transplant Nephrologists

被引：2

作者：

Rodriguez-Ramirez, Sonia ^{[1
,2
]}

Kim, S. Joseph ^{[1
,2
,3
]}

机构：

[1] Univ Hlth Network, Div Nephrol, Toronto, ON, Canada

[2] Univ Hlth Network, Ajmera Transplant Ctr, Toronto, ON, Canada

[3] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

clinical research; randomized control trial; cohort study; case-control study; cross-sectional study; case report; ANTIBODY; TRIAL; GUIDE; BIAS;

D O I：

10.3389/fimmu.2022.879200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical research is about asking and answering questions. Before solutions relevant to clinical problems can be sought, clinicians must frame questions in ways that are answerable using the methods of clinical research. Different types of questions are best answered using specific study designs. Each design has inherent strengths and limitations. In this review article, we provide an approach to asking answerable clinical research questions, review the major study designs, describe their strengths and weaknesses, and link the study designs to their intended purposes.

引用

页数：12

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