Synthesis of Some Novel Indoline-2,3-Dione Derivatives and the Influence of Gamma Irradiation on Their Biological Activities

被引：2
|
作者：
Mansour, Eman [1 ]
Taher, H. A. [2 ]
El-Farargy, A. F. [3 ]
Elewa, Safaa, I [1 ]
机构：
[1] Ain Shams Univ, Fac Womens Arts Sci & Educ, Organ Chem Dept, Cairo 11767, Egypt
[2] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Atom Energy Author, Cairo, Egypt
[3] Zagazig Univ, Fac Sci, Chem Dept, Zagazig, Egypt
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 10期
关键词：
Indoline-2; 3-dione; thiazoles; phenylisothiocyanate; hydrazonylhalides; antimicrobial activity; gamma radiation; DEINOCOCCUS-RADIODURANS; ISATIN; ANTIFUNGAL; ANTIBACTERIAL; SCHIFF;
D O I：
10.1080/10406638.2021.1991395
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide (4) was synthesized by reaction of 3-hydrazonoindolin-2-one (3) with phenyl isothiocyanate in DMF in presence of potassium hydroxide. Thus, treatment of 4 with the appropriate halo ketones, hydrazonoyl halides, and benzylidene malononitriles afforded thiazolidin-4-one, and thiadiazole derivatives. Moreover, structures of the newly synthesized compounds were elucidated as based of elemental analysis and spectral data. Also, the influence of gamma irradiation on the biological activities of the new compounds was evaluated.
引用
收藏
页码：6846 / 6860
页数：15
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