Synthesis of lipid II phosphonate analogues

被引：6
|
作者：
Borbas, Aniko [2 ]
Herczegh, Pal [1 ]
机构：
[1] Univ Debrecen, Ctr Med & Hlth Sci, Dept Pharmaceut Chem, H-4010 Debrecen, Hungary
[2] Univ Debrecen, Hungarian Acad Sci, Res Grp Carbohydrates, H-4010 Debrecen, Hungary
来源：
CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 12期
关键词：
Lipid II analogues; Conjugate addition; Wadsworth-Horner-Emmons reaction; BACTERIAL TRANSGLYCOSYLASE; BIOSYNTHESIS; INHIBITION; TARGET;
D O I：
10.1016/j.carres.2011.04.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Simple analogues of lipid II were synthesized from 3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-1-thio-beta-D-glucopyranose using conjugate addition onto ethylidene bisphosphonate and subsequent Wadsworth-Horner-Emmons reaction with long chain aliphatic aldehydes. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1628 / 1632
页数：5
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