Helminths, human immunodeficiency virus and tuberculosis

被引:0
|
作者
Borkow, G
Weisman, Z
Leng, QB
Stein, M
Kalinkovich, A
Wolday, D
Bentwich, Z [1 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, R Ben Ari Inst Clin Immunol, IL-76100 Rehovot, Israel
[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, AIDS Ctr, IL-76100 Rehovot, Israel
[3] Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Clin Immunol, IL-76100 Rehovot, Israel
[4] Armauer Hansen Res Inst, Addis Ababa, Ethiopia
关键词
D O I
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中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Helminth infections affect over a quarter of the world's population, especially in the developing countries. These long-lasting parasitic infections cause widespread immune activation and dysregulation, a dominant Th2 cytokine immune profile and an immune hyporesponsiveness state. Considering these profound immune changes and the similar geographic distributions of helminthic infections, HIV and tuberculosis (TB), we suggest that helminthic infections play a major role in the pathogenesis of AIDS and TB. They apparently make the host more susceptible to infection by HIV and Mycobacterium tuberculosis, and impair his/her ability to generate protective immunity against both infections. The implication of these ideas is that without eradication of helminth infections and/or modulation of the immune changes that they cause, HIV and TB vaccines may fail to confer protection against their respective infections in helminth-endemic areas.
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页码:568 / 571
页数:4
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