New screening method for the determination of stability of pharmaceuticals

被引：33
|
作者：
Simon, P
Veverka, M
Okuliar, J
机构：
[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Dept Phys Chem, SK-81237 Bratislava, Slovakia
[2] Bel Bovamann Int Ltd, Bratislava 81571, Slovakia
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 270卷 / 1-2期
关键词：
induction period; non-isothermal and isotermal kinetics; DSC; pharmaceuticals; oxidation stability;
D O I：
10.1016/j.ijpharm.2003.10.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A rapid method for obtaining the parameters describing the lengths of oxidation induction periods from non-isothermal differential scanning calorimetry measurements, based on the dependence of onset temperature of the oxidation peak on heating rate, is presented. The method has been applied for screening the stability of a set of three pharmaceuticals. The order of stabilities of the compounds obtained by the method coincides with the order determined by classical stability tests. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：21 / 26
页数：6
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