Pharmacokinetics and tissue distribution of piperine in animals after iv. bolus administration

被引：0
|
作者：
Sunkara, G [1 ]
Mada, SR [1 ]
Vobalaboina, V [1 ]
机构：
[1] Kakatiya Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Warangal 506009, Andhra Pradesh, India
来源：
PHARMAZIE | 2001年 / 56卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A reverse phase HPLC method to determine piperine, a pungent constituent of black pepper, in rabbit serum and various tissues of the rat was developed. A pharmacokinetic study was performed in rabbits and tissue distribution studies were carried out in rats. High reproducibility was achieved in quantitative analysis over the concentration range of 0.2-20 mug/ml serum. After bolus intravenous administration of piperine at a dose of 10 mg/kg, the serum concentration - time curve fitted the two-compartment open model. The tissue distribution pattern of pipeline in rats also supports the two-compartment open model.
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页码：640 / 642
页数：3
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