Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

被引：26
|
作者：
Zhang, Pengcheng [1 ]
Konja, Daniels [1 ]
Zhang, Yiwei [1 ]
Wang, Yu [1 ]
机构：
[1] Univ Hong Kong, Dept Pharmacol & Pharm, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China
来源：
CELLS | 2021年 / 10卷 / 09期
关键词：
mitochondria; endoplasmic reticulum; MAM; energy metabolism; CALCIUM SIGNAL TRANSMISSION; MEMBRANE MAM INTEGRITY; CONTACT SITES; INSULIN-RESISTANCE; PHOSPHOLIPID-SYNTHESIS; RYANODINE RECEPTORS; CELL BIOENERGETICS; CA2+ TRANSFER; MITOFUSIN; PKC-ZETA;
D O I：
10.3390/cells10092195
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.
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页数：14
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