Dinuclear silver and gold bisNHC complexes as drug candidates for cancer therapy

被引：9
|
作者：
Quintana, Mireia [1 ]
Rodriguez-Rius, Alba [1 ]
Velle, Alba [2 ]
Vives, Sonia [1 ]
Sanz Miguel, Pablo J. [2 ]
Triola, Gemma [1 ]
机构：
[1] CSIC, Dept Quim Biol, Inst Quim Avanzada Cataluna IQAC, Jordi Girona 18-26, Barcelona 08034, Spain
[2] Univ Zaragoza, Inst Sintesis Quim & Catalisis Homogenea ISQCH, Dept artarnento Quim Inorgan, CSIC, Zaragoza 50009, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2022年 / 67卷
关键词：
Gold; Silver; N -heterocyclic carbene; Ovarian cancer; Oxidative stress; THIOREDOXIN REDUCTASE; CARBENE COMPLEXES; CELL-LINES; INHIBITION; APOPTOSIS; MECHANISMS; EXPRESSION; REACTIVITY; PLATINUM; SYSTEM;
D O I：
10.1016/j.bmc.2022.116814
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report four dinuclear silver(I) and gold(I) complexes containing two different bidentate N-heterocyclic carbene ligands (bisNHC). One of these complexes 4, shows strong and selective anticancer activity against the human ovarian cancer cell line A2780. Mechanistically, 4 enhances the oxidative stress by stimulating reactive oxygen species production and inhibiting the scavenging activity of thioredoxin reductase. Our findings provide evidence that tuning ligand and electronic properties of metal-NHC complexes can modulate their reactivity and selectivity and it may result in potential novel anticancer drugs.
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页数：8
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